Single-nucleotide polymorphisms
With the knowledge of bioinformatics, design a practical proposal(research plan) for using the novel gene editing technology CRISPR/Cas9 to treat/cure a rare disease Sickle cell anemia.”
Requirements: As the assignment needs
just Explain Everything, and make sure there is no plagiarism. Don’t forget this is Bioinformatics Cours
Answer previewThe first intervention is to use the existing database to search for matches of the CRISPR/Cas9 array in the identified bacterial genome. Second is the analysis of the organization of the Cas novel gene to determine its compatibility with the bacteria genome. A comprehensive analysis of the metagenomic data set is expected to yield the unique architecture of the CRISPR and the Cas gene families. Identified loci from this analysis will be useful to classify CRISPR by identifying the target sites for different patient groups. The specific sickle cell disease genome causing the condition will be used to yield relevant results.
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Single-nucleotide polymorphisms
