Treat cure a Rare Disease Sickle Cell Anemia

With the knowledge of bioinformatics, design a practical proposal(research plan) for using the novel gene editing technology CRISPR/Cas9 to treat/cure a rare disease Sickle cell anemia.”

Requirements: As the assignment needs

just Explain Everything, and make sure there is no plagiarism. Don’t forget this is Bioinformatics Cours

Answer preview

The figure above shows that the technique involves modifying the DNA pattern to modify the gene function. The technique would involve correcting the mutation to cure the condition of sickle cell disease. Even though there are other gene-editing techniques, CRISPR/Cas9 is easily applicable, cost-effective, and highly efficient and can correct sickle cell disease mutation (Demirci et al., 2019; Savić & Schwank, 2016). On applicability, CRISPR/Cas-9 involves using a single guided RNA (SgRNAs) to recruit the target DNA sequence, an adjacent protospacer motif (PAM). Finally, a non-homologous joining repairs the associated gene, and synthetic DNA induces the desired changes. CRISPR-Cas9 may be introduced to a zygote for a permanent modification of the gene to eliminate the condition from the family lineage.

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Treat cure a Rare Disease Sickle Cell Anemia